Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression
نویسندگان
چکیده
منابع مشابه
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
We conducted a genome-wide association study to identify novel genes influencing diastolic blood pressure (BP) response to hydrochlorothiazide, a commonly prescribed thiazide diuretic preferred for the treatment of high BP. Affymetrix GeneChip Human Mapping 100K Arrays were used to measure single nucleotide polymorphisms across the 22 autosomes in 194 non-Hispanic black subjects and 195 non-His...
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To identify novel genes influencing blood pressure response to thiazide diuretic therapy for hypertension, we conducted genome-wide association meta-analyses of ≈1.1 million single-nucleotide polymorphisms in a combined sample of 424 European Americans with primary hypertension treated with hydrochlorothiazide from the Pharmacogenomic Evaluation of Antihypertensive Responses study (n=228) and t...
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Only Apolipoprotein E polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority of the underlying genetic effect. To identify additional LOAD risk loci, we performed a genome-wide association study (GWAS) on 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip. An additional 238 cases and 2...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2012
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2012.4